The Effects of Enalapril Maleate and Cold Stress on Some Blood Parameters

Enalapril is a highly specific, competitive inhibitor of angiotensin converting enzyme (ACE) belonging to the category of ACE inhibitors. The beneficial effects of ACE inhibitors appear to result primarily the suppression of the plasma renin-angiotensin-aldesteron system. The pharmacological actions of enalapril maleate are related to hypotension. Enalapril maleate is an ACE inhibitor that controls high blood pressure by relaxing blood vessels. Stress triggers important adaptive responses that enable an organism to cope with a changing environment. The release of catecholamine is a key initial event in responses to stressors and is followed by an increase in the expression of genes that encode catecholamine-synthesizing enzymes. This study is designed to detect the effects of enalapril maleate and cold stress on blood glucose, triglyceride, cholesterol, and albumin levels in rat sera. Cold stress treatment has increased blood glucose, cholesterol and triglyceride levels but albumin level has decreased (P<0.05). Enalapril maleate treatment has decreased blood glucose and triglyceride levels (P<0.05). Cholesterol and albumin levels have not changed (P>0,05). Cold stress+enalapril maleate treatment has decreased blood glucose level (P<0.05). Triglyceride, cholesterol and albumin levels have not changed (P>0,05).